Psychoactive Salvias  

Salvia guaranitica var Black Mammoth
by various on SAB forum

Thelema (April 5, 2002):
SALVIA GUARANITICA var BLACK EMPEROR
VERY strong splendens-like effects. Enough to smoke just one air dried leaf. Partner also attained. Stay tuned...I encourage someone to do a 5X on this one....


Alchemist (April 5, 2002):
S.GUARANITICA contains cirsiliol (dissimilar to salvia terpenes) and is known to be a hypnotic and sedative.

here's an abstract from: Sedative and hypnotic properties of Salvia guaranitica and of its active principle, cirsiliol. Viola, H.; Wasowski, C.; Marder, M.; Wolfman, C.; Paladini, A. C.; Medina, J. H. Fac. Medicina, Univ. Buenos Aires, Buenos Aires, Argent. Phytomedicine (1997), 4(1), 47-52. CODEN: PYTOEY ISSN: 0944-7113. Journal written in English. CAN 127:85915 AN 1997:332220 CAPLUS

"The pharmacol. properties of S. guaranitica exts. and of its active principle cirsiliol were investigated. A partially purified fraction of this plant, administered i.p. in mice (in a dose equiv. to 3 g of the fresh plant) exhibited sedative and hypnotic effects. In the pentobarbital-induced sleep test, cirsiliol (2-10 mg/kg, i.p.) exhibited a dose-dependent hypnotic action. Cirsiliol was more potent in displacing 3H zolpidem binding (Ki = 20 mM) than 3H flunitrazepam binding (Ki = 200 mM) to benzodiazepine receptors from rat cerebral cortex."

And another Central nervous system effects of natural and synthetic flavonoids. Viola, Haydee; Marder, Mariel; Wolfman, Claudia; Wasowski, Cristina; Medina, Jorge H.; Paladini, Alejandro C. Inst. de Biologia Celular y Neurosciencias, Facultad de Medicina, Univ. de Buenos Aires, Buenos Aires, Argent. An. Asoc. Quim. Argent. (1998), 86(3-6), 229-236. CODEN: AAQAAE ISSN: 0365-0375. Journal written in English. CAN 130:218145 AN 1999:24397 CAPLUS

Abstract
Flavonoids are naturally occurring mols. present in the human diet. We demonstrate that some flavonoids possess central nervous system effects, acting through the central benzodiazepine receptors. The pharmacol. characterization of chrysin (5,7-dihydroxyflavone) and apigenin (5,7,4'-trihydroxyflavone), isolated from Passiflora coerulea and Matricaria recutita, resp., showed their anxiolytic, but not myorelaxant or amnesic effects. Cirsiliol (5,3',4'-trihydroxy-6,7-dimethoxyflavone), however, isolated from Salvia guaranitica, had sedative-depressant properties. We were able to increase the biochem. and pharmacol. potency of the natural flavonoids by means of the addn. of halo and/or nitro groups to the flavone nucleus. Some flavonoids are partial agonists of the benzodiazepine receptors and may become new therapeutic drugs, devoid of the unwanted side effects of classical benzodiazepines.